There are TWO STEPS:
Your liver inactivates oestrogen by attaching a little molecule called conjugation. For this step to be successful the liver needs to be clear of toxic overload. The two main contributors of toxic overload are:
Endocrine disrupting Chemicals (for another blog)
The conjugated oestrogen is then eliminated via the gut.
We have a collection of microbes in our gut called the Oestrobolome. This modulates the our Gut-Liver circulation of oestrogen and affects the elimination process of oestrogen.
The Oestrobolome produce an enzyme called Beta-glucuronidase which either removes conjugated oestrogen via our stool OR deconjugates and reactivates oestrogen.
When our gut micro biome is healthy and we have a healthy balance of bacteria present, they are able to assist with regulating the process of the Oestrobolome to metabolise and detoxify Oestrogen via our stool. BUT it is when our gut micro microbiome is imbalanced, known as DYSBIOSIS, oestrogen is deconjugated, reactivated and circulated again through the body. This is where we develop EXCESS OESTROGEN.